Early Stage Gum Disease
Early stage gum disease (Gingivitis) is often undetectable. An accumulation of dental plaque releases fatty acids and other biologically active substances including lipopolysaccharides (LPS) and chemotactic peptides such as f-MLP. These chemicals are soluble and quickly penetrate the outer layers of the gum tissue entering the epithelium. Chemotactic peptides signal neutrophils (white blood cells) to enter the epithelium and produce pro-inflammatory agents known as cytokines. Salivary glands also begin to produce antibacterial agents.